Nitric oxide has become one of the most studied molecules in human physiology. The 1998 Nobel Prize-winning discovery triggered an eruption of research that now confirms nitric oxide's natural ability to prevent clotting, regulate inflammation, revitalize tissue, kill invading microorganisms, and even eradicate cancer cells. Click through the primer above to learn about nitric oxide and its essential role in the body.
The documented ability of nitric oxide to regulate inflammation, revitalize tissue, increase local blood flow and kill bacteria, make nitric oxide an ideal dermatological therapy.
- Clinical science
Weller, R. Nitric oxide donors and the skin: useful therapeutic agents?
- Journal of Drugs in Dermatology
Del Rosso, J; Kircik, L. Spotlight on the Use of Nitric Oxide in Dermatology
Zeichner, J. Inflammatory Acne Treatment: Review of Current and New Topical Therapeutic Options
- Journal of Investigative Dermatology
Bruch-Gerharz, D; Ruzicka, T; Kolb-Bachofen, V. Nitric oxide in human skin: current status and future prospects.
- Nitric oxide
Cals-Grierson, M.M.; Ormerod, A.D. Nitric oxide function in the skin.
Schairer, D.O.; Chouake, J.S.; Nosanchuk, J.D.; Friedman, A.J. The potential of nitric oxide releasing therapies as antimicrobial agents.
- Journal of Clinical Investigation
Fang, F. C. Perspectives series: host/pathogen interactions. Mechanisms of nitric oxide-related antimicrobial activity.
- Clinical infectious diseases
De Groote, M. A.; Fang, F. C. NO inhibitions: antimicrobial properties of nitric oxide.
- Nitric oxide
Ghaffari, A.; Miller, C. C.; McMullin, B.; Ghahary, A. Potential application of gaseous nitric oxide as a topical antimicrobial agent.
Saura, M.; Zaragoza, C.; McMillan, A.; Quick, R.A.; Lowenstein, J.M.; Lowenstein, C.J. An antiviral mechanism of nitric oxide: inhibition of a viral protease.
- The Society for Investigative Dermatology
Qin, M.; Landriscina, A.; Rosen, J.; Wei, G.; Kao, S.; Olcott, W.; Agak, G.W.; Paz, K.B.; Boventre, J.; Celndaniel, A.; Harper, S.; Adler, B.; Krausz, A.; Friedman, J.; Nosanchuk, J.; Kim, J.; Friedman, A.J. Nitric oxide releasing nanoparticles prevent Propionibacterium acnes induced inflammation by both clearing the organism and inhibiting microbial stimulation of the innate immune response.
- Annals of the Rheumatic Diseases
Niedbala, W.; Cai, B.; Liew, F.Y.; Role of nitric oxide in the regulation of T cell functions.
Few active ingredients, if any, have the potential to affect as many disease pathologies as nitric oxide. But as a gaseous and highly reactive substance, nitric oxide has been limited by the inability to stably store and safely deliver the right amount, to the right location, at the right time...