Novan has created targeted technology with anti-microbial and anti-inflammatory properties for skin diseases with unmet needs. We recognized a lack of innovation in the dermatology space where patients still want novel topical therapies as alternatives to conventional antibiotics, steroids, biologics, or in-office procedures.
Anti-viral properties of nitric oxide are well characterized in the literature. Researchers have demonstrated nitric oxide’s ability to inhibit viral replication of human papillomavirus (HPV) which if left untreated, high-risk strains can progress to certain cancers. Nitric oxide therapy can be used as an additional line of treatment to complement preventative vaccines.
There is a natural relationship between nitric oxide and the gut. Numerous gastrointestinal diseases result from undesired inflammation and/or an imbalance in the gut microbiome. We believe there is an opportunity with Novan’s nitric oxide technology to develop safe, well-tolerated product candidates that could be used in combination with or as an alternative to conventional therapies for some GI diseases.